bs-7549R [Primary Antibody]
GAS 6 Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: GAS 6

Immunogen Range: 551-650/721


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 2621

Swiss Prot: Q14393

Source: KLH conjugated synthetic peptide derived from human GAS 6

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Background:

Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 76


Cross Reactive Species: Human
Mouse

Predicted Cross Reactive Species: Rat
Dog
Cow
Pig
Horse
Chicken

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Xu et al. "Characterization of porcine GAS6 cDNA gene and its expression analysis in weaned piglets." Genetics and Molecular Research (2015)Read more>>
  • Zhou, Hang. et al. AXL kinase-mediated astrocytic phagocytosis modulates outcomes of traumatic brain injury. J Neuroinflamm. 2021 Dec;18(1):1-17Read more>>
  • Shanyu Fang. et al. NTNG1 Modulates Cisplatin Resistance in Epithelial Ovarian Cancer Cells via the GAS6/AXL/Akt Pathway. Front Cell Dev Biol. 2021; 9: 652325Read more>>
  • Dai Jing-Cong. et al. GAS6-mediated dialogue between decidual stromal cells and macrophages is essential for early pregnancy maintenance by inducing M2-like polarization and cell proliferation of decidual macrophages. Mol Hum Reprod. 2022 Mar;28(3)Read more>>
  • Wangrui Lei. et al. Psoralidin protects against cerebral hypoxia/reoxygenation injury: Role of GAS6/Axl signaling. PHYTOTHER RES. 2022 May 18Read more>>
  • Olivia Justynski. et al. Apoptosis recognition receptors regulate skin tissue repair in mice. ELIFE. 2023 DecRead more>>
  • Wencheng Di. et al. Pterostilbene protects against H2O2-induced oxidative stress by regulating GAS6/Axl signaling in HL-1 cells. CELL BIOCHEM FUNCT. 2024 Feb;42(2):e3956Read more>>
  • Xiaoyue Guan. et al. The Role of Macrophage Efferocytosis in the Pathogenesis of Apical Periodontitis. INT J MOL SCI. 2024 Jan;25(7):3854Read more>>
VALIDATION IMAGES

Lane 1: Mouse liver lysates Lane 2: Mouse kidney lysates probed with Rabbit Anti-GAS 6 Polyclonal Antibody, Unconjugated (bs-7549R) at 1:300 overnight at 4˚C. Followed by a conjugated secondary antibody (bs-0295G-HRP) at 1:5000 for 90 min at RT.


Formalin-fixed and paraffin embedded human lung carcinoma labeled with Rabbit Anti-GAS 6 Polyclonal Antibody, Unconjugated (bs-7549R) at 1:200 followed by conjugation to the secondary antibody and DAB staining