bs-75498C

DATASHEET

Formulation Solid

Storage: Stable for 2 years after receipt when stored at +4°C.

Product Information:

CAS Number: 98319-26-7

Molecular formula: C23H36N2O2

Molecular weight: 372.5

Purity: >98% (HPLC)

Appearance: White to off-white solid.

Solubility: Soluble in DMSO, DMF, ethanol or methanol. Sparingly soluble in water.

InChiKey: DBEPLOCGEIEOCV-WSBQPABSSA-N

SMILES: [H][C@@]12CC[C@H](C(=O)NC(C)(C)C)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])NC(=O)C=C[C@]12C

Description:

Potent, specific and competitive inhibitor of type II 5alpha-reductase (enzyme which converts testosterone to the more potent 5alpha-dihydrotestosterone) [1, 3]. Anticancer compound [2, 6, 7]. Apoptosis modulator [2, 6]. Enhances the action of GABA at GABA(A) receptors, which leads to neurological implications [4]. Inhibit testosterone-induced type I procollagen and TGF-beta1 expression in human scalp dermal fibroblasts in a model of androgenic alopecia [5]. Drug for the treatment of male androgenetic alopecia [8]. Potential role in neuropsychiatric disorders [9]. Shown to reduce L-DOPA-induced dyskinesia in rodent models for Parkinson’s disease [10].