bs-75478C

DATASHEET

Formulation Powder

Storage: Stable for 2 years after receipt when stored at -20°C.

Product Information:

CAS Number: 477-30-5

Molecular formula: C21H25NO5

Molecular weight: 371.4

Purity: >98% (HPLC)

Appearance: White to off-white powder.

Solubility: Soluble in ethanol, DMSO or chloroform.

InChiKey: NNJPGOLRFBJNIW-HNNXBMFYSA-N

SMILES: O=C1C(OC)=CC=C(C([C@@H](NC)CC2)=C1)C3=C2C=C(OC)C(OC)=C3OC

Description:

Anti-cancer compound [2, 6, 7, 10, 11, 14]. Cell synchronization agent. Used as a drug in chemotherapy by synchronizing tumor cells at metaphase, the radiosensitive stage of the cell cycle [11, 12, 14]. Microtubule assembly inhibitor. Depolymerizes microtubules and limits microtubule formation (inactivates spindle fibre formation) [1, 4, 5, 14]. Inhibits mitosis during cell division at metaphase by inhibiting spindle formation [2, 5, 7, 8, 14]. Low concentrations affect microtubule dynamics and cell migration, while high concentrations promote microtubule detachment from microtubule organizing center [14]. Apoptosis inducer [9, 13]. Thrombopoietic agent [3].