bs-75466C

DATASHEET

Formulation Powder

Storage: Stable for 2 years after receipt when stored at -20°C.

Product Information:

CAS Number: 183241-73-8

Molecular formula: C12H15NO4 . C2H3O2

Molecular weight: 237.3 . 59.0

Purity: >95% (HPLC)

Appearance: White to off-white powder.

Solubility: Soluble in water.

InChiKey: TXEKHKMVDUMVBF-GNAZCLTHSA-M

SMILES: C[C@H](O)C(N[C@@H](CC1=CC=CC=C1)C(O)=O)=O.CC([O-2])=O

Description:

Lac-Phe is an exercise-inducible metabolite, also called exerkine, that suppresses feeding and obesity. Lac-Phe is increased heavily with exercise in mammals and acts to reduce food intake and potentially decrease overall body weight and fat mass. In diet-induced obese mice, pharmacological administration of Lac-Phe led to decreased food intake, adiposity and body weight, as well as improved glucose homeostasis, while movement and energy expenditure were not affected. The biosynthesis of Lac-Phe from lactate and phenylalanine occurs in CNDP2+ cells, including macrophages, monocytes and other immune and epithelial cells.