bs-75459C

DATASHEET

Formulation Powder

Storage: Stable for 2 years after receipt when stored at -20°C.

Product Information:

CAS Number: 73210-73-8

Molecular formula: C16H25N3O5 • 1/2C4H4O4

Molecular weight: 339.4 . 58.0

Purity: >98% (NMR)

Appearance: White to off-white powder.

Solubility: Soluble in water (20mg/ml) or DMSO (40mg/ml).

InChiKey: LVVMVDRJXOBQNA-WLHGVMLRSA-N

SMILES: O=C(NCC[NH2+]CC(O)COC1=CC=C(O)C=C1)N2CCOCC2.[O-]C(/C=C/C(O)=O)=O

Description:

A phenoxypropanolamine derivative that is a selective partial agonist of beta1-adrenergic receptors (beta1-ARs) (pA2 values are 7.4 - 7.8 and 5.2 - 6.2 at beta1- and beta2-adrenoceptors, respectively), and has shown to improve systolic and diastolic function in studies with heart failure patients. It modulates the sympathetic control of the heart but has no agonist action on beta2-adrenoceptors. Xamoterol has an EC50 value of 80nM for the generation of cyclic AMP (cAMP) in neonatal rat cardiomyocyte cultures. It increases spontaneous contraction of isolated rat right atria (EC50 = 4.67nM). In vivo, xamoterol increases heart rate, an effect that is reversed by the selective beta1-AR antagonist betaxolol but not the selective beta2-AR antagonist ICI 118551.