bs-75451C
[Life Science]
IHR-1
DATASHEET
Formulation Solid
Storage: Stable for 1 year after receipt when stored at -20°C.
Product Information:
CAS Number: 548779-60-8
Molecular formula: C20H12Cl4N2O2
Molecular weight: 454.1
Purity: >98% (NMR)
Appearance: White to grey solid.
Solubility: Soluble in DMSO.
InChiKey: VCLHHRGZKNUOAQ-UHFFFAOYSA-N
SMILES: ClC1=CC(C(=O)NC2=CC=C(NC(=O)C3=CC(Cl)=CC=C3Cl)C=C2)=C(Cl)C=C1
Molecular formula: C20H12Cl4N2O2
Molecular weight: 454.1
Purity: >98% (NMR)
Appearance: White to grey solid.
Solubility: Soluble in DMSO.
InChiKey: VCLHHRGZKNUOAQ-UHFFFAOYSA-N
SMILES: ClC1=CC(C(=O)NC2=CC=C(NC(=O)C3=CC(Cl)=CC=C3Cl)C=C2)=C(Cl)C=C1
Description:
Sonic hedgehog (Shh) signaling pathway inhibitor. Potential anticancer compound. Cell membrane impermeable Smoothened (Smo) antagonist. Acts on extracellularly exposed Smo only. Binds to the seven-transmembrane (7TM) pocket. Blocks hedgehog-induced movement of Smo into the primary cilium, disengages Smo-dependent abrogation of Gli2 and Gli3 proteolytic processing and inhibits Gli activity induced by loss of PTCH1.
Size: 1mg,5mg,
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.