bs-75440C
[Life Science]
RO-3306
DATASHEET
Formulation Solid
Storage: Stable for 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
Product Information:
CAS Number: 872573-93-8
Molecular formula: C18H13N3OS2
Molecular weight: 351.5
Purity: >95% (NMR)
Appearance: Brown solid.
Solubility: Soluble in DMSO.
InChiKey: XOLMRFUGOINFDQ-YBEGLDIGSA-N
SMILES: O=C1N=C(NCC2=CC=CS2)S\C1=C/C1=CC2=C(C=C1)N=CC=C2
Molecular formula: C18H13N3OS2
Molecular weight: 351.5
Purity: >95% (NMR)
Appearance: Brown solid.
Solubility: Soluble in DMSO.
InChiKey: XOLMRFUGOINFDQ-YBEGLDIGSA-N
SMILES: O=C1N=C(NCC2=CC=CS2)S\C1=C/C1=CC2=C(C=C1)N=CC=C2
Description:
Selective CDK 1 inhibitor (Cdk1/B1 and Cdk1/A) [1-3, 5]. Potential anti-cancer compound [1, 8]. Cell cycle arrest inducer at G1, S and G2/M [2, 7] . Apoptosis inducer in embryonic stem cells [4]. Actively enhances downstream p53 signaling to promote apoptosis in AML cell lines [6]. Suppresses phosphorylation of p53 at Ser315 and procaspase-8 at Ser387 [8, 9]. Enhances Fas-mediated activation and processing of procaspase-8 in mitotic cells towards [9].
Size: 1mg,5mg,25mg,
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.