DATASHEET
Formulation
Solid
Storage:
Stable for 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
Product Information:
CAS Number: 329196-48-7
Molecular formula: C26H26ClN3O4
Molecular weight: 480
Purity: >95% (NMR)
Appearance: White to off-white solid.
Solubility: Soluble in DMSO, ethanol or chloroform.
InChiKey: VQOJFGFKIVFMDH-UHFFFAOYSA-N
SMILES: CCOC1=CC(=CC(OCC)=C1OCC)C(=O)NC1=CC(C2=NC3=C(N2)C=CC=C3)=C(Cl)C=C1
Description:
Sonic hedgehog (Shh) signaling pathway modulator. Cell permeable potent smoothened (Smo) antagonist. Inhibits wt and oncogenic Smo. SAG activity (Prod. Nr. AG-CR1-3506) inhibitor. Gli1 reporter gene expression inhibitor. Suppresses the Shh-dependent translocation of Smo to the primary cilium. Potential tumor growth blocker.