bs-75438C

DATASHEET

Formulation Solid

Storage: Stable for 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.

Product Information:

CAS Number: 106740-09-4

Molecular formula: C11H16NO2PS2 . C4H9NO

Molecular weight: 288.4 . 87.1

Purity: >95% (NMR)

Appearance: White solid.

Solubility: Soluble in DMSO or water.

InChiKey: YZMHNNLDUWRZFW-UHFFFAOYSA-N

SMILES: C1COCC[NH2+]1.COC1=CC=C(C=C1)P([S-])(=S)N1CCOCC1

Description:

Water-soluble, slow-releasing hydrogen sulfide (H2S) donor [1]. Exhibits vasodilator and antihypertensive activity [1, 2, 4]. Anti-inflammatory [2, 3]. Inhibits LPS-induced release of proinflammatory mediators (IL-1beta, IL-6, TNF-alpha, nitric oxide (NO) and PGE2) and increases the synthesis of the anti-inflammatory chemokine IL-10 through NF-kappaB, ATF-2 and HSP27 dependent pathways [2, 3]. Causes stomatal opening and reduces nitric oxide accumulation in plants [5]. Oxidative stress-induced cell death inhibitor [6]. Shows novel anti-cancer effects in vitro and in vivo [7]. Anti-thrombotic via p-selectin dependent mechanism [8].