bs-75425C

DATASHEET

Formulation Solid

Storage: Stable for 2 years after receipt when stored at -20°C.

Product Information:

CAS Number: 54857-86-2

Molecular formula: C19H32O4

Molecular weight: 324.5

Purity: >98%

Appearance: White to off-white solid.

Solubility: Soluble in DMSO (10mg/ml), DMF (5mg/ml) or ethanol (5mg/ml).

InChiKey: CZRCFAOMWRAFIC-UHFFFAOYSA-N

SMILES: CCCCCCCCCCCCCCOC1=CC=C(C(O)=O)O1

Description:

Fatty acid synthase (FASN) inhibitor. Cell permeable, potent, reversible and competitive inhibitor of acetyl-CoA carboxylase (ACC) consequently blocking the synthesis of malonyl-CoA. Useful agent for immunometabolism research. Anticancer agent. Induces apoptosis in a variety of tumor cell lines. Relatively non-cytotoxic to various cancer cell lines. TOFA-induced reduction in malonyl-CoA is reported to off-set the effect of C75 (AG-CR1-2904) on food intake in fasted mice and on apoptosis in tumor cells. Hypolipidemic agent. Stimulates citrate accumulation in the cell, which leads to a suppression of glycolysis by citrate-induced inhibition of phosphofructokinase.