bs-75424C
[Life Science]
Purvalanol A
DATASHEET
Formulation Powder
Storage: Stable for 2 years after receipt when stored at -20°C.
Product Information:
CAS Number: 212844-53-6
Molecular formula: C19H25ClN6O
Molecular weight: 388.9
Purity: >98% (HPLC)
Appearance: Off-white powder.
Solubility: Soluble in DMSO (30mg/ml), ethanol (10mg/ml), DMF (50mg/ml), methanol or dichloromethane.
InChiKey: PMXCMJLOPOFPBT-HNNXBMFYSA-N
SMILES: ClC1=CC=CC(NC2=C3C(N(C(C)C)C=N3)=NC(N[C@@H](CO)C(C)C)=N2)=C1
Molecular formula: C19H25ClN6O
Molecular weight: 388.9
Purity: >98% (HPLC)
Appearance: Off-white powder.
Solubility: Soluble in DMSO (30mg/ml), ethanol (10mg/ml), DMF (50mg/ml), methanol or dichloromethane.
InChiKey: PMXCMJLOPOFPBT-HNNXBMFYSA-N
SMILES: ClC1=CC=CC(NC2=C3C(N(C(C)C)C=N3)=NC(N[C@@H](CO)C(C)C)=N2)=C1
Description:
Potent, cell permeable cyclin-dependent protein kinase (cdk) inhibitor. Inhibits human CDK1 (IC50=4nM), CDK2/cyclin A (IC50=70nM), Cdc2/cyclin B, CDK2/cyclin E (IC50=35nM), CDK4/cyclin D1 (IC50=850nM) as well as CDK5/p35 (IC50=75nM). DYRK1A inhibitor (IC50=300nM). Anticancer agent. Strong apoptotic and autophagy inducer which causes cell cycle arrest in the G1 and G2 phase in various cancer cell lines. More membrane permeable than purvalanol B. Shown to inhibit ABCB1 and ABCB2 transporters and useful in co-treatment with selected anticancer drugs.
Size: 1mg,5mg,
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.