bs-75417C

DATASHEET

Formulation Solid

Storage: Stable for 2 years after receipt when stored at -20°C.

Product Information:

CAS Number: 1346526-26-8

Molecular formula: C13H10N2O

Molecular weight: 210.2

Purity: >98% (HPLC)

Appearance: Off-white to tan solid.

Solubility: Soluble in DMSO (2mg/ml), ethanol or methanol. Insoluble in water.

InChiKey: XZQLYCMLGSOHOX-UHFFFAOYSA-N

SMILES: OC(C=C1)=CC=C1C2=CC3=CC=CN=C3N2

Description:

Specific competitive RIPK1 inhibitor in vitro (IC50=1.03µM). Binds to human RIPK1 adenosine triphosphate-binding site and locks it in an inactive conformation to block necroptosis. Necroptosis contributes to the pathogenesis of several inflammatory diseases including ischemic reperfusion injury, acute pancreatitis, sepsis, neurodegeneration, viral infection and liver diseases. Inhibits both TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis in FADD-deficient Jurkat cells (EC50=1.2µM). Does not block caspase-dependent apoptosis induced by TRAIL, FasL or staurosporine. Protects mice from concanavalin A-induced hepatitis in vivo.