DATASHEET
Formulation
Solid
Storage:
Stable for 2 years after receipt when stored at -20°C.
Product Information:
CAS Number: 154447-36-6
Molecular formula: C19H17NO3
Molecular weight: 307.4
Purity: >99% (NMR)
Appearance: White to off-white crystalline solid.
Solubility: Soluble in DMSO, 100% ethanol or methanol.
InChiKey: CZQHHVNHHHRRDU-UHFFFAOYSA-N
SMILES: O=C1C=C(OC2=C(C=CC=C12)C1=CC=CC=C1)N1CCOCC1
Description:
Potent, cell permeable, highly specific, reversible PI(3)K (phosphoinositide 3-kinase) inhibitor. pan-class I / II / III PI3K inhibitor. Acts on the ATP-binding site of the enzyme. In solution more stable than wortmannin. Antagonizes P-glycoprotein-mediated multidrug resistance. Blocks Akt phosphorylation. Pim-1 kinase inhibitor. Autophagy inhibitor (autophagosome formation). Inhibitor of BET bromodomain proteins BRD2, BRD3 and BRD4.