bs-75395C
[Life Science]
Splitomicin
DATASHEET
Formulation Solid
Storage: Stable for 2 years after receipt when stored at -20°C.
Product Information:
CAS Number: 5690-03-9
Molecular formula: C13H10O2
Molecular weight: 198.2
Purity: >98% (NMR)
Appearance: White to off-white solid.
Solubility: Soluble in methanol, ethanol or DMSO.
InChiKey: ISFPDBUKMJDAJH-UHFFFAOYSA-N
SMILES: O=C1CCC2=C(O1)C=CC1=CC=CC=C21
Molecular formula: C13H10O2
Molecular weight: 198.2
Purity: >98% (NMR)
Appearance: White to off-white solid.
Solubility: Soluble in methanol, ethanol or DMSO.
InChiKey: ISFPDBUKMJDAJH-UHFFFAOYSA-N
SMILES: O=C1CCC2=C(O1)C=CC1=CC=CC=C21
Description:
Potent cell permeable and selective inhibitor of yeast NAD+-dependent histone deacetylase (HDAC) Sir2p [1-4]. Displays higher activity in vivo than in vitro [1-4]. Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket [5]. Shown to have diverse effects also in mammalian cells [6-10].
Size: 1mg,5mg,25mg,
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.