bs-75392C

DATASHEET

Formulation Solid

Storage: Stable for 2 years after receipt when stored at -20°C.

Product Information:

CAS Number: 3895-92-9

Molecular formula: C21H18ClNO4

Molecular weight: 383.8

Purity: >98% (NMR)

Appearance: Yellow to dark yellow solid.

Solubility: Soluble in DMSO, ethanol, methanol or water (2mg/ml warm).

InChiKey: WEEFNMFMNMASJY-UHFFFAOYSA-M

SMILES: [Cl-].COC1=C(OC)C2=C(C=C1)C1=C(C3=C(C=C1)C=C1OCOC1=C3)[N+](C)=C2

Description:

Cell permeable potent inhibitor of protein kinase C. Does not inhibit tyrosine protein kinases, cAMP-dependent protein kinase or calcium/calmodulin-dependent protein kinase [1, 5]. Antiplatelet, anti-inflammatory, antibacterial and antitumor compound [1, 2, 9, 12, 15]. Apoptosis inducer in cancer cells in vitro and in vivo [3, 9]. Activates MAPK and JUNK signaling pathways [4, 8]. Affects translocation of PKC from cytosol to plasma membrane [6]. Neurite outgrowth stimulator [7]. Inhibits binding of BclXL to Bak (IC50 = 1.5 µM) or Bad proteins and stimulates apoptosis in several cancer cell lines [10, 13]. Blocks human P2X7 receptor [11]. Induces cell cycle arrest in G1 phase [14]. Specific cyclooxygenase-2 inhibitor [15].