bs-75363C
[Life Science]
PD 184,352
DATASHEET
Formulation Solid
Storage: Stable for 2 years after receipt when stored at -20°C.
Product Information:
CAS Number: 212631-79-3
Molecular formula: C17H14ClF2IN2O2
Molecular weight: 478.7
Purity: >98% (HPLC)
Appearance: White to off-white solid.
Solubility: Soluble in DMSO.
InChiKey: GFMMXOIFOQCCGU-UHFFFAOYSA-N
SMILES: FC1=C(F)C(NC2=CC=C(I)C=C2Cl)=C(C=C1)C(=O)NOCC1CC1
Molecular formula: C17H14ClF2IN2O2
Molecular weight: 478.7
Purity: >98% (HPLC)
Appearance: White to off-white solid.
Solubility: Soluble in DMSO.
InChiKey: GFMMXOIFOQCCGU-UHFFFAOYSA-N
SMILES: FC1=C(F)C(NC2=CC=C(I)C=C2Cl)=C(C=C1)C(=O)NOCC1CC1
Description:
MEK (MAPKK) inhibitor [5]. Potent and selective MAPK (ERK kinase 1; MEK1) activation inhibitor (IC50 = 300 nM in vitro, IC50 = 2 nM in vivo) [1, 2]. Suppresses activation of MAPK but does not block its activity [3]. Antiproliferative [4]. Causes cell-cycle arrest in G1 phase [4]. Tumor suppressor [1, 5]. Apoptosis inducer [6].
Size: 1mg,5mg,
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.