bs-75350C
[Life Science]
DAPT
DATASHEET
Formulation Solid
Storage: Stable for 2 years after receipt when stored at -20°C.
Product Information:
CAS Number: 208255-80-5
Molecular formula: C23H26F2N2O4
Molecular weight: 432.5
Purity: >98% (NMR)
Appearance: White to off-white solid.
Solubility: Soluble in 100% ethanol, DMSO (20 mg/ml) or dichloromethane.
InChiKey: DWJXYEABWRJFSP-XOBRGWDASA-N
SMILES: C[C@H](NC(=O)CC1=CC(F)=CC(F)=C1)C(=O)N[C@H](C(=O)OC(C)(C)C)C1=CC=CC=C1
Molecular formula: C23H26F2N2O4
Molecular weight: 432.5
Purity: >98% (NMR)
Appearance: White to off-white solid.
Solubility: Soluble in 100% ethanol, DMSO (20 mg/ml) or dichloromethane.
InChiKey: DWJXYEABWRJFSP-XOBRGWDASA-N
SMILES: C[C@H](NC(=O)CC1=CC(F)=CC(F)=C1)C(=O)N[C@H](C(=O)OC(C)(C)C)C1=CC=CC=C1
Description:
Cell permeable gamma-secretase inhibitor (IC50 = 115 nM for total beta-amyloid, IC50 = 200 nM for beta-amyloid 1-42) [1]. Reduces Abeta levels in vivo [2]. Blocks the proteolytic processing of neurotrophin receptor alike death domain protein (NRADD) [3]. Does not inhibit persenilinase [4]. Notch processing inhibitor [5]. Enhances neuronal differentiation independent of sonic hedgehog (Shh) signaling [6]. CDK5 activity inhibitor [7]. Apoptosis enhancer [8]. Inhibitor of slurp-like1 expression in the floor plate of the neural tube.
Size: 5mg,25mg,
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.