bs-75345C
[Life Science]
Bisindolylmaleimide I (free base) [GF-109203X; Gö 6850]
DATASHEET
Formulation Solid
Storage: Stable for 2 years after receipt when stored at -20°C.
Product Information:
CAS Number: 133052-90-1
Molecular formula: C25H24N4O2
Molecular weight: 412.5
Purity: >97% (NMR)
Appearance: Orange solid.
Solubility: Soluble in DMSO.
InChiKey: QMGUOJYZJKLOLH-UHFFFAOYSA-N
SMILES: CN(C)CCCN1C=C(C2=C1C=CC=C2)C1=C(C(=O)NC1=O)C1=CNC2=C1C=CC=C2
Molecular formula: C25H24N4O2
Molecular weight: 412.5
Purity: >97% (NMR)
Appearance: Orange solid.
Solubility: Soluble in DMSO.
InChiKey: QMGUOJYZJKLOLH-UHFFFAOYSA-N
SMILES: CN(C)CCCN1C=C(C2=C1C=CC=C2)C1=C(C(=O)NC1=O)C1=CNC2=C1C=CC=C2
Description:
Cell permeable kinase inhibitor with improved selectivity for protein kinase C (PKC) (Ki = 10 nM) [1]. Competetive inhibitor for the ATP-binding site of PKC [1]. Anti-inflammatory [2]. Binds to P-glycoprotein [3]. Telomerase activity inhibitor [4]. Potent glycogen synthase kinase-3 (GSK-3) inhibitor [5]. Necrosis inhibitor [6]. Blocks hERG potassium channels [7-9]. Promotes osteoblastogenesis in human mesenchymal stem cells [10].
Size: 1mg,5mg,
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.