bs-75313C
[Life Science]
Boc-Asp(OMe)-FMK
DATASHEET
Formulation Powder
Storage: Stable for 3 years after receipt when stored at -20°C.
Product Information:
CAS Number: 187389-53-3
Molecular formula: C11H18FNO5
Molecular weight: 263.3
Purity: >98%
Appearance: White to off-white powder.
Solubility: Soluble in ethanol (5mg/ml), DMSO or DMF (both 30mg/ml).
InChiKey: IPYYWMLWOBWDDP-UHFFFAOYSA-N
SMILES: FCC([C@@H](NC(OC(C)(C)C)=O)C(OC)=O)=O
Molecular formula: C11H18FNO5
Molecular weight: 263.3
Purity: >98%
Appearance: White to off-white powder.
Solubility: Soluble in ethanol (5mg/ml), DMSO or DMF (both 30mg/ml).
InChiKey: IPYYWMLWOBWDDP-UHFFFAOYSA-N
SMILES: FCC([C@@H](NC(OC(C)(C)C)=O)C(OC)=O)=O
Description:
Cell permeable, irreversible, broad-spectrum caspase inhibitor. Inhibits non-caspase cysteine proteases, as well as cathepsins H and L. Can be used for in vitro and in vivo studies. Contains a methyl ester group, which facilitates uptake by cells and subsequently is removed by cytoplasmic esterases, leaving the functional inhibitor. Inhibits the pro-apoptotic effect of TNF-alpha (IC50=39µM). Shown to reduce the activation of NF-kB, suppresses the phosphorylation of IkBalpha and inhibits TNF-induced expression of ICAM-1 and VCAM-1. Blocks hepatocyte apoptosis in vivo. Neuroprotective.
Size: 1mg,5mg,
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.