bs-75297C
[Life Science]
Z-Leu-Leu-Leu-CHO [MG-132]
DATASHEET
Formulation Solid
Storage: Stable for 2 years after receipt when stored at -20°C.
Product Information:
CAS Number: 133407-82-6
Molecular formula: C26H41N3O5
Molecular weight: 475.6
Purity: >97% (HPLC)
Appearance: White solid.
Solubility: Soluble in DMSO or ethanol.
InChiKey: TZYWCYJVHRLUCT-VABKMULXSA-N
SMILES: [H]C(=O)[C@]([H])(CC(C)C)NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@]([H])(CC(C)C)NC(=O)OCC1=CC=CC=C1
Molecular formula: C26H41N3O5
Molecular weight: 475.6
Purity: >97% (HPLC)
Appearance: White solid.
Solubility: Soluble in DMSO or ethanol.
InChiKey: TZYWCYJVHRLUCT-VABKMULXSA-N
SMILES: [H]C(=O)[C@]([H])(CC(C)C)NC(=O)[C@]([H])(CC(C)C)NC(=O)[C@]([H])(CC(C)C)NC(=O)OCC1=CC=CC=C1
Description:
Potent, cell permeable and selective, reversible proteasome inhibitor [2, 7]. Blocks degradation of short-lived proteins and induces a heat shock response [2, 6, 7]. NF-kappaB activation inhibitor through IkappaB degradation [3, 8]. Cell permeable, reversible peptide aldehyde inhibitor. Calpain and cathepsin inhibitor [4, 11]. Has anticancer properties by inducing cell cycle arrest and activating apoptosis in various cancer cell lines [8, 9, 12,13,15]. Has adjuvant/chemosensitizer potential [8]. Neurite outgrowth stimulator in PC12 cells [1]. Prevents beta-secretase cleavage [5, 10]. Autophagy activator [12, 14].
Size: 1mg,5mg,25mg,
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.