DATASHEET
Formulation
Solid
Storage:
Stable for 3 years after receipt when stored at -20°C.
Product Information:
CAS Number: 1381885-28-4 (free base)
Molecular formula: C31H49FN10O6 . C2HF3O2
Molecular weight: 676.8 . 114.0
Purity: >90% (HPLC)
Appearance: White to slightly yellow solid.
Solubility: Soluble in water (1mg/ml).
InChiKey: DYQKGOBRZWMAHV-YTJMMMLMSA-N
SMILES: OC(=O)C(F)(F)F.CC(C)[C@H](NC(=O)OCC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NC(CCCNC(N)=N)C(=O)CF
Description:
Selective cell permeable and irreversible MALT1 inhibitor. Inhibits NF-kappaB-dependent gene expression and affects the growth, proliferation and survival of activated B cell-like diffuse large B cell lymphomas (ABC-DLBCL) and germinal center B cell like diffuse large B cell lymphoma (GCB-DLBCL) cell lines. Shown to inhibit the autoprocessing activity of MCA2ac (calcium dependent) in Trypanosoma brucei.