bs-75289C
[Life Science]
Z-VAD-FMK (Cell permeable)
DATASHEET
Formulation Solid
Storage: Stable for 3 years after receipt when stored at -20°C.
Product Information:
CAS Number: 187389-52-2 and 634911-81-2
Molecular formula: C22H30FN3O7
Molecular weight: 467.5
Purity: >95% (HPLC)
Appearance: White solid.
Solubility: Soluble in DMSO, acetonitrile or dimethyl formamide.
InChiKey: MIFGOLAMNLSLGH-SXUUOERCBK
SMILES: [H][C@](NC(=O)OCC1=CC=CC=C1)(C(C)C)C(=O)N[C@@H](C)C(=O)NC(CC(=O)OC)C(=O)CF
Molecular formula: C22H30FN3O7
Molecular weight: 467.5
Purity: >95% (HPLC)
Appearance: White solid.
Solubility: Soluble in DMSO, acetonitrile or dimethyl formamide.
InChiKey: MIFGOLAMNLSLGH-SXUUOERCBK
SMILES: [H][C@](NC(=O)OCC1=CC=CC=C1)(C(C)C)C(=O)N[C@@H](C)C(=O)NC(CC(=O)OC)C(=O)CF
Description:
Cell permeable, non-selective broad-spectrum caspase inhibitor [1, 3, 7, 8]. Binds irreversibly to the catalytic site of caspase proteases [1]. The peptide is O-methylated in the P1 position on aspartic acid, providing enhanced stability and increased cell permeability [1]. Inhibits ICE-family protease/caspase processing, leading to apoptosis and autophagy induction [2-4, 6, 9]. Decreases proteasome activity [5]. Potent inhibitor of caspase-1 activation in NLRP3/NALP3-induced cells [10]. Used in apoptosis and inflammasome studies.
Size: 1mg,5mg,
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.