bs-75279C

DATASHEET

Formulation Oil

Storage: Stable for 2 years after receipt when stored at -20°C.

Product Information:

CAS Number: 149183-75-5

Molecular formula: C17H20O6

Molecular weight: 320.3

Purity: >97% (HPLC)

Appearance: Yellow to amber oil.

Solubility: Soluble in DMSO, dichloromethane or acetonitrile. Slightly soluble in methanol, ethanol or water (0.1mg/ml).

InChiKey: XLPXUPOZUYGVPD-VMPILDALSA-N

SMILES: OC1=C(O)C=CC(CCOC(C[C@H](CC([H])=O)/C(C([H])=O)=C\C)=O)=C1

Description:

Oleacin is a phenolic compound of extra virgin olive oil and has antioxidant, anti-inflammatory, antitumor, antiproliferative, antimicrobial, cardioprotective, antiobesity and antiatherosclerotic properties. In vitro studies showed that oleacein reduces ROS production by f-MLP and PMA-stimulated neutrophils (inhibiting the release of myeloperoxidase). 5-Lipoxygenase (5-LOX) and NF-kappaB signaling inhibitor. Improves insulin sensitivity in obese mice. Dual substrate-inhibitor of catechol-O-methyltransferase. Inhibits the catalytic activities of nicotinamide N-methyltransferase, ATP-citrate lyase, lysine-specific demethylase 6A and N-methyltransferase 4.