bs-75273C

DATASHEET

Formulation Solid

Storage: Stable for 1 year after receipt when stored at -20°C.

Product Information:

CAS Number: 14306-25-3 (anhydrous)

Molecular formula: C6H12O24P6 . xNa . yH2O

Molecular weight: 660.0 (anhydrous free acid)

Purity: >98%

Appearance: White solid.

Solubility: Soluble in water (50mg/ml).

InChiKey: IMQLKJBTEOYOSI-GPIVLXJGSA-N

SMILES: O=P(O)(O)O[C@H]1[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H]1OP(O)(O)=O

Description:

Direct activator of necroptosis inducer MLKL (mixed lineage kinase domain-like). Necroptosis is an inflammatory form of programmed cell death executed through plasma membrane rupture by the pseudokinase mixed lineage kinase domain-like (MLKL). Addition of IP6 promotes membrane permeabilization by MLKL through directly binding of the N-terminal executioner domain (NED) and dissociating its auto-inhibitory region. IP6 is a phosphate ester of inositol (Ins) and precursor for second messengers in cell signaling. Iron (Fe) Chelator that binds also to Ca, Mg, Zn. Considered as an anti-nutritional component in cereals, seeds and beans that binds these minerals and prevents their absorption in the gastrointestinal tract. Formulations containing phytic acid have been used as preservatives in food production. Antioxidant with anticancer, anti-inflammatory, antidiabetic, neuroprotective, hypocholesterolemic and hypolipidemic effects. Shown to inhibit lipid peroxidation and inhibits proliferation of a variety of cancer cells in vitro and reduces tumor growth in rodent xenograft models. Increases insulin sensitivity in adipocytes by increasing lipid storage capacity, improving glucose uptake and inhibiting lipolysis. Shown to have in vitro and in vivo antidiabetic activity. Shown to modulate gut microbiota and to have a key role in several stages of the HIV-1 lifecycle from assembly to uncoating.