bs-75272C

DATASHEET

Formulation Solid

Storage: Stable for 2 years after receipt when stored at -20°C.

Product Information:

CAS Number: 82-08-6

Molecular formula: C30H28O8

Molecular weight: 516.5

Purity: >98% (HPLC)

Appearance: Orange to brown solid.

Solubility: Soluble in DMSO (50mg/ml) or ethanol (1mg/ml). Insoluble in water.

InChiKey: DEZFNHCVIZBHBI-ZHACJKMWSA-N

SMILES: CC1(C)C=CC2=C(O)C(CC3=C(O)C(C)=C(O)C(C(C)=O)=C3O)=C(O)C(C(/C=C/C4=CC=CC=C4)=O)=C2O1

Description:

Anticancer agent that can inhibit cell growth, induce apoptosis, autophagy and cell cycle arrest, inhibit cell invasion and shows anti-angiogenic activity. OXPHOS inhibitor. Mitochondrial uncoupler that depolarizes the mitochondrial membrane potential, reduces cellular ATP levels, activates 5'-AMP-activated protein kinase (AMPK) and affects mitochondrial production of reactive oxygen species (ROS). Useful for immunometabolism research. Potent activator of multiple Ca2+-sensitive K+ channels. Naturally occurring hERG channel activator. Antioxidant and ROS scavanger. Might have cardioprotective effects. Has been widely used as a selective inhibitor of protein kinase Cdelta (PKCdelta) (IC50=3-6µM), although there has been controversy in the literature over this claim. Inhibits CAM kinase III and a wide range of other kinases and non-kinase proteins in vitro. Most potently inhibits PRAK and MAPKAP-K2. Induces autophagy by inhibition of mTORC1 signaling. Displays neuroprotective effects.