DATASHEET
Formulation
Solid
Storage:
Stable for 2 years after receipt when stored at -20°C.
Product Information:
CAS Number: 64925-80-0
Molecular formula: C36H45ClN6O12
Molecular weight: 789.2
Purity: >98% (HPLC, TLC)
Appearance: White solid.
Solubility: Soluble in DMSO (10mg/ml), ethanol, methanol (5mg/ml) or DMF.
InChiKey: FAFRRYBYQKPKSY-KBIMZEDXSA-N
SMILES: ClC1=CC([C@H](O)[C@@H]2NC)=CC(O[C@@](C)(CC)[C@H](C(N3CC=C[C@H]3C(N/C(C(N/C(C(O)=O)=C/C(O)=O)=O)=C(C)/CC)=O)=O)NC([C@H](C(C)=C)NC2=O)=O)=C1O
Description:
Macrocyclic heptapeptide mycotoxin. Potent anti-mitotic compound that can cause cell death. Microtubule assembly inhibitor. Binds selectively to dimeric tubulin, inhibiting the formation of the microtubule spindle to block cell division. Binds at a site different from the colchicine binding site and overlapping the vinblastine binding site. Inhibits tubulin-dependent GTP hydrolysis. Binds beta-tubulin from higher organisms but not alpha-tubulin or fungal mycelial tubulin. Causes lupinosis (a degenerative disorder) in livestock fed infected lupins.