DATASHEET
Formulation
Powder
Storage:
Stable for 2 years after receipt when stored at -20°C.
Product Information:
CAS Number: 78518-73-7
Molecular formula: C30H52O4
Molecular weight: 476.7
Purity: >98% (HPLC)
Appearance: White to off-white lyophilized powder.
Solubility: Soluble in DMSO or 100% ethanol (25mg/ml).
InChiKey: LVWWPNAIMBYRKG-KOHQYJKCSA-N
SMILES: CC(O1)(C)[C@H](O)CC[C@@]2(C)[C@@]1([H])CC[C@@](O)(C)[C@@H]2CC[C@@H]3C(C)(C)[C@@](CC[C@@]4(C)O)([H])[C@@]4([H])CC=C3C
Description:
Efficient inhibitor of P-glycoprotein (Pgp, MDR-1) function through direct interactions. By inhibiting MDR-1, active compounds remain in the cytoplasm longer and allowing them to be more effective within the cell. Reversing agent for the treatment of multidrug resistance (MDR) in Pgp-overexpressing tumors. Potentiates the cytotoxicity of established Pgp substrates such as colchicine, vinblastine and paclitaxel. Antiproliferative and cytotoxic compound. Potent antifouling compound.