bs-75240C

DATASHEET

Formulation Solid

Storage: Stable for 2 years after receipt when stored at -20°C.

Product Information:

CAS Number: 13289-18-4

Molecular formula: C36H52O15

Molecular weight: 724.8

Purity: >99% (HPLC and UV Absorbance)

Appearance: White to off-white solid.

Solubility: Soluble in water (~4mg/ml).

InChiKey: DCSLTSSPIJWEJN-YRFFWODSSA-N

SMILES: [H]C(=O)[C@]12CC[C@@H](C[C@@]1(O)CCC1C2CC[C@]2(C)[C@H](CC[C@]12O)C1=COC(=O)C=C1)O[C@@H]1OC(C)[C@H](O[C@@H]2OC(CO)[C@@H](O)[C@@H](O)C2O)[C@H](O)C1O

Description:

Highly potent Na+/K+-ATPase inhibitor, blocking the active efflux of Na+ and reuptake of K+. Water soluble cardiotonic glycoside from the class of bufadienolides (with 2-pyrone ring). Inhibits cancer cell growth in vitro. Shown to induce caspase-dependent apoptosis, reducing MDR resistance and the rate of mitochondrial oxidative phosphorylation in cancer cells. Inotropic by increasing the intracellular Ca2+ concentration. Immunosuppressive and anti-inflammatory agent that inhibits allogeneic T cell activation with much higher potency than cortisol or cyclosporin A. Anti-seizure activity in pentylenetetrazole (PTZ)-induced epileptical seizures.