bs-75238C
[Life Science]
Cucurbitacin B
DATASHEET
Formulation Powder
Storage: Stable for 2 years after receipt when stored at -20°C.
Product Information:
CAS Number: 6199-67-3
Molecular formula: C32H46O8
Molecular weight: 558.7
Purity: >98% (HPLC)
Appearance: Off-white powder.
Solubility: Soluble in DMSO.
InChiKey: IXQKXEUSCPEQRD-DKRGWESNSA-N
SMILES: [H][C@@]1([C@H](O)C[C@@]2(C)[C@]3([H])CC=C4[C@@]([H])(C[C@H](O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@]12C)[C@@](C)(O)C(=O)\C=C\C(C)(C)OC(C)=O
Molecular formula: C32H46O8
Molecular weight: 558.7
Purity: >98% (HPLC)
Appearance: Off-white powder.
Solubility: Soluble in DMSO.
InChiKey: IXQKXEUSCPEQRD-DKRGWESNSA-N
SMILES: [H][C@@]1([C@H](O)C[C@@]2(C)[C@]3([H])CC=C4[C@@]([H])(C[C@H](O)C(=O)C4(C)C)[C@]3(C)C(=O)C[C@]12C)[C@@](C)(O)C(=O)\C=C\C(C)(C)OC(C)=O
Description:
Microtubule polymerization inhibitor. Disrupts F-actin and induces nucleophosmin/B23 translocation. Immunomodulator with antimicrobial, anti-inflammatory and antitumorigenic properties. Induces apoptosis, autophagy and cell cycle arrest at G2/M phase in a range of cancer cell lines. Shown to inhibit STAT 3 phosphorylation and expression levels and blocks JAK2 activity, as well as the transcriptional activity of HIF1alpha and NF-kappaB. Antioxidant. Serves as an ecdysteroid receptor antagonist in Drosophila.
Size: 1mg,5mg,25mg,
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.