bs-75228C

DATASHEET

Formulation Solid

Storage: Stable for 2 years after receipt when stored at -20°C.

Product Information:

CAS Number: 80489-90-3

Molecular formula: C21H24O4

Molecular weight: 340.4

Purity: >97% (HPLC)

Appearance: Solid.

Solubility: Soluble in DMSO, ethanol or methanol. Insoluble in water.

InChiKey: CTNFTPUIYFUXBE-UHFFFAOYSA-N

SMILES: COC1=C(CC=C(C)C)C(O)=C(C(O)=O)C(CCC2=CC=CC=C2)=C1

Description:

Antidiabetic agent. Potent and selective partial agonist of peroxisome proliferator-activated receptor gamma (PPARgamma), a nuclear receptor regulating lipid and glucose metabolism. Has nanomolar binding affinity to PPARgamma and micromolar binding to the isotypes PPARalpha and PPARbeta/delta. Glucose-lowering agent. Improves insulin sensitivity, glucose tolerance and blood lipid variables without increase of fat storage or hepatoxicity. Shows potent PPARgamma-dependent anti-inflammatory activity. Potent NF-kappaB activation inhibitor by the suppression of IkappaBalpha degradation, p65 nuclear translocation and DNA-binding activity. Antimicrobial agent.