DATASHEET
Formulation
Solid
Storage:
Stable for 2 years after receipt when stored at +4°C.
Product Information:
CAS Number: 24280-93-1
Molecular formula: C17H20O6
Molecular weight: 320.3
Purity: >98% (HPLC, TLC)
Appearance: White to off-white solid.
Solubility: Soluble in DMSO, methanol or ethanol. Insoluble in water.
InChiKey: HPNSFSBZBAHARI-RUDMXATFSA-N
SMILES: COC1=C(C)C2=C(C(=O)OC2)C(O)=C1C\C=C(/C)CCC(O)=O
Description:
Antibiotic [1]. Shows antiviral, antifungal and antitumor properties [1, 2]. Immunosuppressive drug used to prevent rejection in organ transplantation, rheumatoid arthritis, and psoriasis [3-6, 13]. Potent reversible inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH), leading to depletion of GMP and interruption of the de novo synthesis of purine nucleotides necessary for B and T lymphocyte proliferation [7, 8]. Inhibits the type II IMPDH isoform (IMPDH-2) 5-fold more potently compared to type I isoform [11]. Inhibits RNA and DNA synthesis [13]. Inducible nitric oxide synthase (iNOS/NOS II) inhibitor [8, 10]. Apoptosis and necrosis inducer [9, 12]. Novel type of inhibitor against RNA guanylyltransferases [14]. Inhibits TNF-alpha-stimulated MAPK/NF-kappaB and ROS generation [15]. Autophagy suppressor. Broad-spectrum antiviral compound with inhibitory activity against different coronavirus, including SARS-CoV, MERS-CoV and SARS-CoV-2, cause of COVID-19. It binds to the active site of SARS-CoV-2 papain-like protease (PLpro) possibly inhibiting viral replication.
Size:
100mg, , 500mg , 500mg
Applications:
Life Science()
For research use only. Not intended for diagnostic or therapeutic use.