bs-75147C

DATASHEET

Formulation Solid

Storage: Stable for 2 years after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Product Information:

CAS Number: 57186-25-1

Molecular formula: C27H33NO4

Molecular weight: 435.6

Purity: >95% (HPLC)

Appearance: Off-white solid.

Solubility: Soluble in DMSO, methanol or ethanol (all at least 1mg/ml).

InChiKey: ACNHBCIZLNNLRS-UBGQALKQSA-N

SMILES: [H][C@]12CC3=C(NC4=C3C=CC=C4)[C@]1(C)[C@@]1(C)CC[C@]3([H])O[C@@H](C(=O)C=C3[C@]1(O)CC2)C(C)(C)O

Description:

Tremorgenic [1]. Potent, selective and reversible inhibitor of high-conductance calcium-activated potassium (BKCa) channels [2]. Reversible inhibitor of inositol 1,4,5-trisphosphate receptor (InsP(3)) [3]. Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) inhibitor [4]. Liver X receptor (LXRalpha and LXRbeta; NR1H3 and NR1H2) agonist in biochemical and in vitro cell-based assays [5]. Anticonvulsant [6]. Apoptosis enhancer. Can sensitize various glioma cells to TRAIL-mediated apoptosis [7]. Shown to protect neuronal cells against glutamate-induced cell death [8].