bs-75083C

DATASHEET

Formulation Solid

Storage: Stable for 3 years after receipt when stored at -20°C.

Product Information:

CAS Number: 518-75-2

Molecular formula: C13H14O5

Molecular weight: 250.3

Purity: >97% (HPLC)

Appearance: Yellow solid.

Solubility: Soluble in methanol, ethanol, methylene chloride, pyridine or dioxane. Insoluble in water, chloroform or hexane.

InChiKey: CQIUKKVOEOPUDV-IYSWYEEDSA-N

SMILES: C[C@H]1OC=C2C(O)=C(C(O)=O)C(=O)C(C)=C2[C@@H]1C

Description:

Antibiotic [1, 2]. Antiprotozoal. Antimicrobial [3, 6]. Cytotoxic and genotoxic in various mammalian cells [4]. Mitochondrial permeability transition pore (MPTP) activator [5-7]. Apoptosis inducer [7-9, 14]. ERK and JNK signaling pathways activator [10]. Nephrotoxic mycotoxin [11]. Suppresses NO and iNOS expression via inhibition of the JAK/STAT-1alpha and NF-kappaB signaling pathways [12]. Tubulin polymerization and mitotic spindle assembly inhibitor [13]. Increases reactive oxygen species (ROS) [14]. Induces cell cycle arrest at the G0/G1 and G2/M phase [13,14].