bs-75080C

DATASHEET

Formulation Solid

Storage: Stable for 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark. Stock solutions are stable for 3 months when stored at -20°C.

Product Information:

CAS Number: 85753-43-1

Molecular formula: C20H13N3O

Molecular weight: 311.4

Purity: >97% (HPLC)

Appearance: Off-white to yellow crystalline solid.

Solubility: Soluble in DMSO or methanol. Insoluble in water.

InChiKey: MEXUTNIFSHFQRG-UHFFFAOYSA-N

SMILES: O=C1NCC2=C1C1=C(NC3=C1C=CC=C3)C1=C2C2=C(N1)C=CC=C2

Description:

Indolocarbazole alkaloid antibiotic. [1]. Potent cell permeable reversible and ATP-competitive PKC (protein kinase C) inhibitor with 10-fold selectivity over PKA (protein kinase A) [1-5]. Anticancer compound. Cytotoxic againt various cancer cell lines [6, 9,11]. Apoptosis inducer [11]. Antiviral compound against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV) [7]. LACTB (beta-lactamase), malate dehydrogenase (MDH2, MDHC, MDH1B, ME1. ME2, ME3) and chymotrypsin inhibitor [8]. Inhibits mixed lineage kinase (MLK) [10].