bs-75077C
[Life Science]
Apicidin
DATASHEET
Formulation Solid
Storage: Stable for 1 year after receipt when stored at -20°C. Stock solutions are stable for 3 months when stored at -20°C.
Product Information:
CAS Number: 183506-66-3
Molecular formula: C34H49N5O6
Molecular weight: 623.8
Purity: >98% (HPLC, TLC)
Appearance: White to off-white solid.
Solubility: Soluble in ethanol or DMSO.
InChiKey: JWOGUUIOCYMBPV-LQJYRIKDSA-N
SMILES: [H][C@]12CCCCN1C(=O)[C@@]([H])(NC(=O)[C@H](CC1=CN(OC)C3=C1C=CC=C3)NC(=O)[C@H](CCCCCC(=O)CC)NC2=O)C(C)CC
Molecular formula: C34H49N5O6
Molecular weight: 623.8
Purity: >98% (HPLC, TLC)
Appearance: White to off-white solid.
Solubility: Soluble in ethanol or DMSO.
InChiKey: JWOGUUIOCYMBPV-LQJYRIKDSA-N
SMILES: [H][C@]12CCCCN1C(=O)[C@@]([H])(NC(=O)[C@H](CC1=CN(OC)C3=C1C=CC=C3)NC(=O)[C@H](CCCCCC(=O)CC)NC2=O)C(C)CC
Description:
Antiprotozoal [1]. Potent inhibitor of histone deacetylase (HDAC) [1,2]. Inhibits proliferation [2,3]. Induces cell cycle arrest at the G1 phase [2]. Induces hyperacetylation of histone H4 [5]. Apoptosis inducer [4,8,9]. Potent anti-angiogenic compound [5-7]. Decreases HIF-1alpha protein levels and transcriptional activity in human and mouse tumor cell lines [3]. Autophagy inducer in oral squamous cell carcinoma (OSCC) cells [8]. Promotes either self-renewal or differentiation of embryonic stem cells [10].
Size: 1mg,5mg,
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.