bs-75046C

DATASHEET

Formulation Solid

Storage: Stable for 2 years after receipt when stored at -20°C.

Product Information:

CAS Number: 109581-93-3

Molecular formula: C44H69NO12 . H2O

Molecular weight: 804.0 . 18.0

Purity: >98% (HPLC)

Appearance: White to off-white solid.

Solubility: Soluble in DMSO, ethanol, methanol, ethyl acetate or acetone. Insoluble in water.

InChiKey: NWJQLQGQZSIBAF-CBLXODBSSA-N

SMILES: [H]O[H].[H][C@]1(CC[C@@]([H])(O)[C@@]([H])(C1)OC)\C=C(/C)[C@@]1([H])OC(=O)C2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@]([H])([C@H](C[C@@]2([H])C)OC)[C@]([H])(C[C@@]([H])(C)C\C(C)=C\[C@@]([H])(CC=C)C(=O)CC(O)[C@@]1([H])C)OC

Description:

Potent immunosuppressant (as cyclosporin A and rapamycin) [1-3]. Suppresses proliferation of cytotoxic T cells and inhibits the production of T cell-derived mediators such as interleukin-2 (IL-2) [2, 4]. Forms a complex with FK-506 binding protein 12 (FKBP12). Inhibits the activity of the calcium/calmodulin-dependent protein phosphatase 2B (PP2B; calcineurin), leading to disruption of T cell activation [2, 4, 6, 7]. Prevents rejection of transplanted organs [3]. Anti-inflammatory compound in the treatment of several inflammatory skin diseases (e.g. atopic dermatitis) and with potential anti-rheumatic activity (rheumatoid arthritis) [5, 9]. Neuroprotective. Regulates nitric oxide neurotoxicity. Neurotransmitter. Ca2+ release compound [8]. NF-kappaB suppressor by induction of unfolded protein response (UPR) [11]. Anti-cancer compound. Apoptosis inducer [10, 12].