bs-7210C
[Life Science]
dBRD9-A
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 779.88
Formula: C42 H49 N7 O8
CAS Number: 2170679-42-0
InChi Key: ZDINQSNMYRVAGP-UHFFFAOYSA-N
InChi: InChI=1S/C42H49N7O8/c1-47(23-31-34(56-3)20-26(21-35(31)57-4)30-24-48(2)40(53)29-22-43-19-16-27(29)30)25-37(51)45-18-10-8-6-5-7-9-17-44-32-13-11-12-28-38(32)42(55)49(41(28)54)33-14-15-36(50)46-39(33)52/h11-13,16,19-22,24,33,44H,5-10,14-15,17-18,23,25H2,1-4H3,(H,45,51)(H,46,50,52)
Smiles: CN(CC(=O)NCCCCCCCCNC1C=CC=C2C=1C(=O)N(C1CCC(=O)NC1=O)C2=O)CC1C(=CC(=CC=1OC)C1=CN(C)C(=O)C2=CN=CC=C12)OC
Purity: 98.0
Solubility: Soluble in DMSO
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C42 H49 N7 O8
CAS Number: 2170679-42-0
InChi Key: ZDINQSNMYRVAGP-UHFFFAOYSA-N
InChi: InChI=1S/C42H49N7O8/c1-47(23-31-34(56-3)20-26(21-35(31)57-4)30-24-48(2)40(53)29-22-43-19-16-27(29)30)25-37(51)45-18-10-8-6-5-7-9-17-44-32-13-11-12-28-38(32)42(55)49(41(28)54)33-14-15-36(50)46-39(33)52/h11-13,16,19-22,24,33,44H,5-10,14-15,17-18,23,25H2,1-4H3,(H,45,51)(H,46,50,52)
Smiles: CN(CC(=O)NCCCCCCCCNC1C=CC=C2C=1C(=O)N(C1CCC(=O)NC1=O)C2=O)CC1C(=CC(=CC=1OC)C1=CN(C)C(=O)C2=CN=CC=C12)OC
Purity: 98.0
Solubility: Soluble in DMSO
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
dBRD9-A is a potent BRD9 degrader that selectively binds BRD9 and elicits near complete degradation of BRD9 at nanomolar concentrations. It was shown to inhibit the growth of synovial sarcoma cells in vitro and tumor progression in a synovial sarcoma xenograft mouse model.
Size: 10mg solid,2mg solid 10mg solid,2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.