bs-7158C
[Life Science]
Deschloroclozapine
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 292.38
Formula: C18 H20 N4
CAS Number: 1977-07-7
InChi Key: VQHITFFJBFOMBG-UHFFFAOYSA-N
InChi: InChI=1S/C18H20N4/c1-21-10-12-22(13-11-21)18-14-6-2-3-7-15(14)19-16-8-4-5-9-17(16)20-18/h2-9,19H,10-13H2,1H3
Smiles: CN1CCN(CC1)C1=NC2C=CC=CC=2NC2C=CC=CC=21
Purity: 98.0
Solubility: Soluble in DMSO
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C18 H20 N4
CAS Number: 1977-07-7
InChi Key: VQHITFFJBFOMBG-UHFFFAOYSA-N
InChi: InChI=1S/C18H20N4/c1-21-10-12-22(13-11-21)18-14-6-2-3-7-15(14)19-16-8-4-5-9-17(16)20-18/h2-9,19H,10-13H2,1H3
Smiles: CN1CCN(CC1)C1=NC2C=CC=CC=2NC2C=CC=CC=21
Purity: 98.0
Solubility: Soluble in DMSO
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
Deschloroclozapine is a high affinity and highly potent activator of muscarinic DREADDs. It is a derivative of clozapine, and exhibits 100-fold greater affinity for hM3Dq and hM4Di compared to clozapine N-oxide, and 50-fold greater affinity compared to DREADD agonist 21. Deschloroclozapine displays low 'off-target' receptor binding and rapid binding and activation of hM3Dq and hM4Di in mice and non-human primates. It also induces spatial memory deficits in non-human primates expressing hM4Di in the prefrontal cortex.
Size: 10mg solid, 2mg solid 10mg solid, 2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.