bs-7157R-BF647 [Conjugated Primary Antibody]
Mitoferrin 2 Polyclonal Antibody, AbBy Fluor® 647 Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: Mitoferrin 2

Immunogen Range: 271-364/364


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 81894

Swiss Prot: Q96A46

Source: KLH conjugated synthetic peptide derived from human Mitoferrin 2

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Mitoferrin 2, also known as MRS3/4 (mitochondrial RNA-splicing protein 3/4 homolog), mitochondrial iron transporter 2, NPD016, MRS4L or SLC25A28 (solute carrier family 25 member 28), is a 364 amino acid multi-pass membrane protein of the mitochondrial inner membrane that mediates iron uptake. Mitoferrin 2 is thought to play a role in heme synthesis of hemoproteins and iron-sulfur cluster assembly. Ubiquitously expressed, Mitoferrin 2 is found at high levels in skeletal muscle, heart, placenta, kidney, lung, liver, brain and pancreas. Mitoferrin 2 is a member of the mitochondrial carrier family and undergoes alternative splicing events to produce four isoforms. Mitoferrin 2 contains three solcar repeats and is encoded by a gene that maps to human chromosome 10q24.2.

Conjugation: AbBy Fluor® 647

Excitation/ Emission: 650nm/665nm

Size: 100ul

Concentration: 1ug/ul

Applications: IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 39


Predicted Cross Reactive Species: Human
Mouse
Rat
Dog
Cow
Sheep
Pig

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Dongchen Wang. et al. Mitoferrin 2 deficiency prevents mitochondrial iron overload-induced endothelial injury and alleviates atherosclerosis. Exp Cell Res. 2021 May;402:112552Read more>>
  • Christine Fischer. et al. Dietary Iron Overload and Hfe?/? Related Hemochromatosis Alter Hepatic Mitochondrial Function. Antioxidants-Basel. 2021 Nov;10(11):1818Read more>>
  • Jingjing Liu. et al. Iron-frataxin involved in the protective effect of quercetin against alcohol-induced liver mitochondrial dysfunction. J NUTR BIOCHEM. 2022 Dec;:109258Read more>>
  • Chiara Buoso. et al. Dopamine?iron homeostasis interaction rescues mitochondrial fitness in Parkinson's disease. NEUROBIOL DIS. 2024 Apr;:106506Read more>>