bs-7125C
[Life Science]
Altiratinib
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 510.46
Formula: C26 H21 F3 N4 O4
CAS Number: 1345847-93-9
InChi Key: GNNDEPIMDAZHRQ-UHFFFAOYSA-N
InChi: InChI=1S/C26H21F3N4O4/c27-15-3-5-16(6-4-15)31-24(35)26(8-9-26)25(36)32-20-12-19(29)21(13-18(20)28)37-17-7-10-30-22(11-17)33-23(34)14-1-2-14/h3-7,10-14H,1-2,8-9H2,(H,31,35)(H,32,36)(H,30,33,34)
Smiles: O=C(NC1C=CC(F)=CC=1)C1(CC1)C(=O)NC1=CC(F)=C(C=C1F)OC1=CC(NC(=O)C2CC2)=NC=C1
Purity: 98.0
Solubility: Soluble in DMSO, not in water
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C26 H21 F3 N4 O4
CAS Number: 1345847-93-9
InChi Key: GNNDEPIMDAZHRQ-UHFFFAOYSA-N
InChi: InChI=1S/C26H21F3N4O4/c27-15-3-5-16(6-4-15)31-24(35)26(8-9-26)25(36)32-20-12-19(29)21(13-18(20)28)37-17-7-10-30-22(11-17)33-23(34)14-1-2-14/h3-7,10-14H,1-2,8-9H2,(H,31,35)(H,32,36)(H,30,33,34)
Smiles: O=C(NC1C=CC(F)=CC=1)C1(CC1)C(=O)NC1=CC(F)=C(C=C1F)OC1=CC(NC(=O)C2CC2)=NC=C1
Purity: 98.0
Solubility: Soluble in DMSO, not in water
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
Altiratinib, also known as DCC-270, DP-5164, is an oral, selective and highly potent inhibitor of MET, TIE2, VEGFR2 and TRK kinases with potential anticancer activity. DCC-2701 effectively reduces tumor burden in vivo and blocks c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with a HGF antagonist in vitro. Importantly, DCC-2701's anti-proliferative activity was dependent on c-MET activation induced by stromal human fibroblasts and to a lesser extent exogenous HGF.
Size: 10mg solid,2mg solid 10mg solid,2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.