bs-7055C
[Life Science]
Defactinib HCl
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 546.95
Formula: C20 H22 Cl F3 N8 O3 S
CAS Number: 1073160-26-5
InChi Key: RCHQNUQAHJNRBY-UHFFFAOYSA-N
InChi: InChI=1S/C20H21F3N8O3S.ClH/c1-24-18(32)12-4-6-13(7-5-12)29-19-28-10-14(20(21,22)23)16(30-19)27-11-15-17(26-9-8-25-15)31(2)35(3,33)34;/h4-10H,11H2,1-3H3,(H,24,32)(H2,27,28,29,30);1H
Smiles: Cl.CNC(=O)C1C=CC(=CC=1)NC1N=C(NCC2=NC=CN=C2N(C)S(C)(=O)=O)C(=CN=1)C(F)(F)F
Purity: 98.0
Solubility: Soluble in DMSO
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C20 H22 Cl F3 N8 O3 S
CAS Number: 1073160-26-5
InChi Key: RCHQNUQAHJNRBY-UHFFFAOYSA-N
InChi: InChI=1S/C20H21F3N8O3S.ClH/c1-24-18(32)12-4-6-13(7-5-12)29-19-28-10-14(20(21,22)23)16(30-19)27-11-15-17(26-9-8-25-15)31(2)35(3,33)34;/h4-10H,11H2,1-3H3,(H,24,32)(H2,27,28,29,30);1H
Smiles: Cl.CNC(=O)C1C=CC(=CC=1)NC1N=C(NCC2=NC=CN=C2N(C)S(C)(=O)=O)C(=CN=1)C(F)(F)F
Purity: 98.0
Solubility: Soluble in DMSO
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
Defactinib, also known as VS-6063 and PF-04554878, is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. FAK inhibitor PF-04554878 inhibits FAK, which may prevent the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt, thus inhibiting tumor cell migration, proliferation and survival.
Size: 10mg solid,2mg solid 10mg solid,2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.