bs-7047C
[Life Science]
ELR510444
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 368.47
Formula: C19 H16 N2 O2 S2
CAS Number: 1233948-35-0
InChi Key: GRYXROIHHXHFND-UHFFFAOYSA-N
InChi: InChI=1S/C19H16N2O2S2/c1-13-3-8-17(9-4-13)25(22,23)21-18-11-15(6-5-14(18)2)19-10-7-16(12-20)24-19/h3-11,21H,1-2H3
Smiles: CC1C=CC(=CC=1NS(=O)(=O)C1C=CC(C)=CC=1)C1=CC=C(C#N)S1
Purity: 98.0
Solubility: Soluble in DMSO, not in water
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C19 H16 N2 O2 S2
CAS Number: 1233948-35-0
InChi Key: GRYXROIHHXHFND-UHFFFAOYSA-N
InChi: InChI=1S/C19H16N2O2S2/c1-13-3-8-17(9-4-13)25(22,23)21-18-11-15(6-5-14(18)2)19-10-7-16(12-20)24-19/h3-11,21H,1-2H3
Smiles: CC1C=CC(=CC=1NS(=O)(=O)C1C=CC(C)=CC=1)C1=CC=C(C#N)S1
Purity: 98.0
Solubility: Soluble in DMSO, not in water
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
ELR510444 is a potent microtube disruptor with potential anticancer activity. ELR510444 has potent microtubule-disrupting activity, causing a loss of cellular microtubules and the formation of aberrant mitotic spindles and leading to mitotic arrest and apoptosis of cancer cells. ELR510444 potently inhibited cell proliferation with an IC(50) value of 30.9 nM in MDA-MB-231 cells, inhibited the rate and extent of purified tubulin assembly, and displaced colchicine from tubulin, indicating that the drug directly interacts with tubulin at the colchicine-binding site.
Size: 10mg solid,2mg solid 10mg solid,2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.