bs-7039C
[Life Science]
SR-717 lithium
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 351.19
Formula: C15 H8 F2 Li N5 O3
CAS Number: 2375421-09-1
InChi Key: ODSAJRWPLSVEHJ-UHFFFAOYSA-M
InChi: InChI=1S/C15H9F2N5O3.Li/c16-9-5-8(15(24)25)12(6-10(9)17)19-14(23)11-1-2-13(21-20-11)22-4-3-18-7-22;/h1-7H,(H,19,23)(H,24,25);/q;+1/p-1
Smiles: [Li+].[O-]C(=O)C1C=C(F)C(F)=CC=1NC(=O)C1=CC=C(N=N1)N1C=NC=C1
Purity: 98.0
Solubility: Soluble in DMSO
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C15 H8 F2 Li N5 O3
CAS Number: 2375421-09-1
InChi Key: ODSAJRWPLSVEHJ-UHFFFAOYSA-M
InChi: InChI=1S/C15H9F2N5O3.Li/c16-9-5-8(15(24)25)12(6-10(9)17)19-14(23)11-1-2-13(21-20-11)22-4-3-18-7-22;/h1-7H,(H,19,23)(H,24,25);/q;+1/p-1
Smiles: [Li+].[O-]C(=O)C1C=C(F)C(F)=CC=1NC(=O)C1=CC=C(N=N1)N1C=NC=C1
Purity: 98.0
Solubility: Soluble in DMSO
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
SR-717 is an agonist of stimulator of interferon genes STING for treating cancer. SR-717 demonstrates broad interspecies and interallelic specificity. SR-717 functions as a direct cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic that induces the same "closed" conformation of STING. SR-717 displayed antitumor activity; promoted the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues; and facilitated antigen cross-priming. SR-717 also induced the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner.
Size: 10mg solid,2mg solid 10mg solid,2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.