bs-70303S

DATASHEET

Host: Sheep

Target Protein: Tyrosine Hydroxylase

Specificity: Specific for endogenous levels of the ~60 kDa tyrosine hydroxylase protein.

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 25085

Swiss Prot: P04177

Source: SDS-denatured, native rat tyrosine hydroxylase purified from pheochromocytoma.

Purification: Antigen Affinity purification from Pooled whole antiserum

Storage Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine and norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999). TH antibodies can also be used to explore basic mechanisms of dopamine and norepinephrine signaling (Witkovsky et al., 2000; Salvatore et al., 2001).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 60

Cross Reactive Species: Human
Mouse
Rat
All mammalian

Predicted Cross Reactive Species: Chicken

For research use only. Not intended for diagnostic or therapeutic use.