bs-70292R

DATASHEET

Host: Rabbit

Target Protein: Trk B

Specificity: Specific for endogenous levels of the ~93 kDa TrkB protein in western blots.

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 25054

Swiss Prot: Q63604

Source: Synthetic peptide corresponding to amino acid residues from the C-terminal region of rat TrkB, conjugated to keyhole limpet hemocyanin (KLH).

Purification: Affinity purification

Storage Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

Tropomyosin-receptor-kinase (TRK) receptors are members of the receptor tyrosine kinase family and include TrkA, TrkB and TrkC. Each of these receptor types has different binding affinities to the neurotrophins nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT-3). TrkB has the highest affinity to binding BDNF which plays critical roles in the function and survival of neurons in the CNS (Soppet et al., 1991; Klein et al., 1991). Additionally, alterations in expression of TrkB have been associated with Alzheimer’s disease (Ferrer et al., 1999; Chen et al., 2008).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 93

Cross Reactive Species: Rat

For research use only. Not intended for diagnostic or therapeutic use.