bs-70289R

DATASHEET

Host: Rabbit

Target Protein: Testicular Receptor 2 (TR2)

Specificity: Specific for endogenous levels of the ~64 kDa TR2 protein.

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 22025

Swiss Prot: Q505F1

Source: Fusion protein from the N-terminal region of mouse TR2.

Purification: Neat whole antiserum

Storage Buffer: Neat whole antiserum

Storage: Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliq

Background:

Testicular receptor 2 (TR2) is a member of the orphan nuclear receptor family. It is widely expressed at a low level throughout the adult testis. TR2 represses transcription and binds DNA directly interacting with HDAC3 and HDAC4 via DNA-binding domains (Franco et al., 2003). TR2 has also been implicated in regulation of estrogen receptor activity in mammary glands (Hun et al., 2002). In addition, TR2 has recently been shown to form a heterodimer with TR4 that can bind to the direct repeat 6 element of the hepatitis B virus (HBV) enhancer II region thus suppressing HBV gene expression (Lin et al., 2008).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 64

Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.