bs-70282R

DATASHEET

Host: Rabbit

Target Protein: TFAM (Transcription Factor A, motochondrial)

Specificity: Specific for endogenous levels of the ~24 kDa TFAM protein. The antibody has been directly tested for reactivity in human. Shows lesser reactivity to rat and mouse due to some sequence homology, but our catalog # 2001-TFAM is recommended for use in rodent.

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 7019

Swiss Prot: Q00059

Source: Native recombinant human TFAM protein with c-terminal 6-his tag.

Purification: Neat whole antiserum

Storage Buffer: Neat whole antiserum

Storage: Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliq

Background:

Mitochondrial Transcription Factor A (TFAM) is a key activator of mitochondrial (mt) DNA transcription as well as a participant in mitochondrial genome replication. mtDNA is highly susceptible to oxidative stress leading to mitochondrial dysfunction. Overexpression of TFAM has been implicated in the amelioration of age dependent impairment of brain functions through the prevention of oxidative stress and mitochondrial dysfunction in microglia (Hayashi et al., 2008). More recently, TFAM overexpression has been shown to potentially reduce oxidative stress in motor neurons and delay onset of amyotrophic lateral sclerosis (ALS) in ALS model mice (Morimoto et al., 2012).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 24

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.