bs-70278R

DATASHEET

Host: Rabbit

Target Protein: TAO2 (Ser181)

Specificity: Specific for endogenous levels of the ~120 kDa TAO2 phosphorylated at Ser181. Immunolabeling is completely eliminated by treatment with λ-phosphatase.

Modification Site: Ser181

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 9344

Swiss Prot: Q9UL54

Source: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser181 of human TAO2, conjugated to keyhole limpet hemocyanin (KLH).

Purification: Antigen Affinity purification from Pooled whole antiserum

Storage Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

In vitro, TAO (thousand and one amino acid) protein kinase 2 (TAO2) activates MAP/ERK kinases (MEKs) 3, 4, and 6 toward their substrates p38 MAP kinase JNK/SAPK (Chen et al., 1999; Chen and Cobb, 2001). This and more recent work has led to the proposal that the TAO protein kinases play an essential role in signaling from physiological agonists to the stress-responsive p38 MAPKs (Chen et al., 2003). Autophosphorylation of TAO may play a role in the mechanism of TAO activation. The MEK binding domain of TAO is autophosphorylated on both serine and threonine residues and Ser-181 is located within this domain.

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 120

Cross Reactive Species: Human
Mouse
Rat

Predicted Cross Reactive Species: Dog
Chicken
Zebrafish
Xenopus
Finch

For research use only. Not intended for diagnostic or therapeutic use.