bs-70274R

DATASHEET

Host: Rabbit

Target Protein: Synaptotagmin 1

Specificity: Specific for endogenous levels of the ~65 kDa synaptotagmin I protein.

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 25716

Swiss Prot: P21707

Source: Synthetic peptide corresponding to amino acid residues specific to rat synaptotagmin 1, conjugated to keyhole limpet hemocyanin (KLH).

Purification: Antigen Affinity purification from Pooled whole antiserum

Storage Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

Synaptotagmin 1 is a synaptic vesicle membrane glycoprotein that is widely expressed throughout the CNS and is generally thought to act as the Ca2+ sensor in the regulation of exocytosis and neurotransmitter release (Littleton and Bellen 1995). Recent studies indicate that synaptotagmin’s Ca2+ mediated binding of SNAP25 is essential for the Ca2+ dependent triggering of membrane fusion (Zhang et al., 2002). It has recently been demonstrated that discrete residues within the c(2)b binding domain of synaptotagmin 1 independently specify endocytic rate and synaptic vesicle size (Poskanzer et al., 2006).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 65

Cross Reactive Species: Mouse
Rat

Predicted Cross Reactive Species: Human
Bovine
Chicken
Non-Human Primate

For research use only. Not intended for diagnostic or therapeutic use.