bs-70257R

DATASHEET

Host: Rabbit

Target Protein: SARS-CoV-2 S-Protein ACE2 Binding Domain

Specificity: Specific for the ~25 kDa ACE2 binding domain construct of SARS-CoV-2 S protein. Full-length CoV-2 S protein is ~142 kDa.

Clonality: Polyclonal

Isotype: IgG

Swiss Prot: P0DTC2

Source: Recombinant SARS-CoV-2 S-Protein construct containing the ACE2 binding domain expressed in and purified from E. coli.

Purification: Antigen Affinity purification

Storage Buffer: PBS + 50% glycerol and 5 mm NaN3

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

The novel SARS-coronavirus 2 (SARS-CoV-2) which causes the disease COVID-19 has been shown to utilize the SARS-CoV receptor ACE2 for entry into human cells (Hoffman, M. et al., Cell 2020). The entry of a coronavirus into host cells is mediated by the viral surface-anchored transmembrane spike (S) glycoprotein which is composed of two functional subunits, S1 which binds the receptor and S2 which fuses the membrane (Walls, AC et.al., Cell 2020). S1 contains a receptor-binding domain (RBD) which specifically recognizes ACE2 as its receptor (Wan, Y. et al., 2020).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 25 or 142 full-length

Cross Reactive Species: SARS-CoV-2

For research use only. Not intended for diagnostic or therapeutic use.